Within the framework of a relativistic mean-field model, I will discuss some relevant nuclear effects that affect neutrino-nucleus cross sections at the energies of interest for neutrino-oscillation experiments: Pauli blocking, binding energies, factorization and hadron final state interactions. I will stress the differences between this relativistic and quantum mechanical approach and the models and methodology that is inside the Monte Carlo neutrino event generators. The results that I will present are mainly based on our recent articles: PRL 123, 052501 (2019); PRC 100, 045501 (2019); PRC 105, 025502 (2022); PRC 105, 054603 (2022).