Motivated by the fermion mass hierarchy we study the phenomenology of two flavorful two-Higgs-doublet model (2HDM) scenarios. By virtue of the flavor or singular alignment ansatz it is possible to link the mass of a subset of fermions to the vacuum-expectation-value (VEV) of a unique Higgs doublet and to simultaneously avoid flavor-changing-neutral-currents at tree-level. We explicitly construct two models called Type-A and B. There, either the top quark alone or all third generation fermions couple to the doublet with the larger VEV. The other fermions acquire their masses through the small VEV of the other doublet. The main differences between these models and conventional ones are studied including a discussion of both their structure and phenomenological consequences.