Muon-electron conversion provides one of the most stringent limits on charged lepton flavor violation. The experimental limit is soon expected to be improved by four orders of magnitude. Higher order corrections are usually described with perturbation theory using an Effective Field Theory (EFT) valid at the nuclear mass. However, muon conversion involves a multiplicity of scales below the nuclear mass, which spoil the convergence of perturbation theory. In this talk, I present a comprehensive framework to overcome this problem, by resorting to a series EFTs. Combining Heavy Quark Effective Theory (HQET), Non-Relativistic QED (NRQED), potential NRQED, Soft-Collinear Effective Theory I and II and boosted HQET, I derive a factorization theorem and present the renormalization group equations.