Mar 9 – 11, 2015
NH Laguna Palace Hotel
Europe/Rome timezone

Contribution to nanomaterials safety assessment: the need of integrating in vitro, in vivo and in silico strategies

Mar 10, 2015, 3:04 PM
Breakout 2 (NH Laguna Palace Hotel)

Breakout 2

NH Laguna Palace Hotel

Viale Ancona, n° 2 30172 Venice-Mestre, Italy Tel: +39 041 829 6111 Fax: +39 848 390 230
Parallel session 4B: Toxicology and human health risks 4B Toxicology and human health risks


Maria Joao Silva (National Institute of Health Doutor Ricardo Jorge)


Fundamental and application-driven research in nanotechnology is expected to boost nanoscience and innovation towards development of safe-by-design nanomaterials (NM). In this scenario, adding vast societal benefits, a multi-disciplinary approach to responsible innovation must be undertaken. Although the widespread use of NM, it is not clear whether they impact on environment and human health, on the long-term. Potential deleterious effects, e.g., genotoxicity that is intimately associated with carcinogenicity, have to be assessed using complementary in vitro and in vivo assays, nested within the conventional risk assessment paradigm and considering specific physicochemical properties of NM. In this study we present the testing strategy that was recently applied to the genotoxicity characterization of titanium dioxide nanomaterials in human cells and in an integrative in vivo model. The results supported the view that a thorough understanding of the relationship between the physicochemical properties, the behaviour of NM in biological systems and their mechanism of action is of utmost importance to predict their biological activity. In conclusion, the knowledge gap between nanoscience and hazard assessment has to be filled within a multi-disciplinary approach including experimental and computational components in an iterative process, towards an improved strategy for the safety evaluation of nanomaterials.

Primary author

Maria Joao Silva (National Institute of Health Doutor Ricardo Jorge)


Henriqueta Louro (National Institute of Health Doutor Ricardo Jorge) José Maria Albuquerque (National Institute of Health Doutor Ricardo Jorge)

Presentation materials