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Mar 9 – 11, 2015
NH Laguna Palace Hotel
Europe/Rome timezone

Distribution and Biological Effects of Fullerene C60, Titanium Dioxide and Silver Nanoparticles after Single and Multiple Intragastrical Administrations to Rats

Mar 11, 2015, 4:00 PM
24m
Breakout 1 (NH Laguna Palace Hotel)

Breakout 1

NH Laguna Palace Hotel

Viale Ancona, n° 2 30172 Venice-Mestre, Italy Tel: +39 041 829 6111 Fax: +39 848 390 230
Parallel Session 6A:Toxicology and human health risks 6AToxicology and human health risks

Speaker

Olga D. Hendrickson (A.N. Bach Institute of Biochemistry, Russian Academy of Sciences)

Description

Additional Authors: Olga V. Morozova, A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, [email protected]; Svetlana M. Pridvorova, A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, [email protected]; Tatyana A. Platonova, A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, [email protected]; Alexander I. Yaropolov, A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, [email protected]; Sergey G. Klochkov, Institute of Physiologically Active Compounds, Russian Academy of Sciences, [email protected]; Sergey O. Bachurin, Institute of Physiologically Active Compounds, Russian Academy of Sciences, [email protected] Abstract: Investigations of the biological effects of nanomaterials, their biodistribution in target organs and tissues after different dosage and routes of exposure are important for assessing the risk of nanotechnology products. The present work is an in-depth study, including the investigation of the localization of fullerene С60, titanium dioxide and silver nanoparticles (NPs) after intragastrical exposure of rats under conditions of acute (single administration) and sub-acute (multiple administrations) toxicity, the observation of the status of experimental animals, pathomorphological analysis of their internal organs, and measurement of the dynamics of key hematological and biochemical parameters. NPs localization in organs of the exposed rats was revealed by mean of different analytical techniques: atomic absorption spectroscopy, transmission electron microscopy, and HPLC with spectrophotometric detection. It was shown that singly or multiply administered NPs absorbed from gastrointestinal tract with infiltration into the bloodstream and translocation into secondary organs. Some biochemical parameters and hematological indices of the treated rats changed in comparison to control animals. However, the exposure did not cause lethality, substantial behavior deviations, water and food consumption, pathomorphology of the internal organs. The amounts of NPs accumulated in organs and tissues are far smaller than the administered dose that is the indication of their efficient excretion. This study was funded by MARINA project (contract № 236215) of the EU 7th Framework Program

Primary author

Olga D. Hendrickson (A.N. Bach Institute of Biochemistry, Russian Academy of Sciences)

Co-authors

Anatoly V. Zherdev (A.N. Bach Institute of Biochemistry, Russian Academy of Sciences) Boris B. Dzantiev (A.N. Bach Institute of Biochemistry, Russian Academy of Sciences)

Presentation materials