Mar 9 – 11, 2015
NH Laguna Palace Hotel
Europe/Rome timezone

Processing Nanoparticles in Suspension of High Solid Concentration: On-line Characterisation and Process Modelling

Mar 9, 2015, 5:18 PM
Breakout 3 (NH Laguna Palace Hotel)

Breakout 3

NH Laguna Palace Hotel

Viale Ancona, n° 2 30172 Venice-Mestre, Italy Tel: +39 041 829 6111 Fax: +39 848 390 230
Parallel session 2C: Industrial decision support tools 2C Industrial decision support tools


Ceyda Oksel (Institute of Particle Science and Engineering, School of Chemical and Process Engineering, University of Leeds)


"Abstract: Manufacture of nanometre particulate form products in suspensions is becoming increasingly important to the pharmaceutical, speciality chemical, and functional material industries. For instance, nano-processing is now used as an effective drug-delivery method for solid form hydrophobic pharmaceuticals due to the dramatically increased drug solubility and bioavailability at nano-scale. The biggest challenge to nano-processing under industrial conditions has been highlighted as the difficulty in achieving consistency in product quality as characterised by particle size distribution. In this work, we report investigation on on-line characterisation and process modelling techniques that can be applied under industrial operational conditions. The research on on-line sensing is based on acoustic spectroscopy for real-time particle sizing. The work will tackle the key challenge posed by multiple scattering and particle-particle interactions, which are known to be the cause leading to incorrect measurement at high solid concentrations. High solid concentration is not only the economically viable range for commercial manufacture of nanoparticles (a much larger reactor would be required to process the same amount of particles in low concentration), but also technically essential for producing ultra-fine particles for many processes. The on-line real-time measurement will provide invaluable data to the development of process models using population balance equations. The focus will be on quantitatively deriving models for particle breakage and aggregation to be used in the population balance equations, as well as intelligent interpretation of the data to improve the qualitative understanding of the process. The process chosen for investigation is wet nano-milling, a very important operation for processing nanoparticles in the pharmaceutical, agrochemical and materials industries. "

Primary author

Xue Z. Wang (Institute of Particle Science and Engineering, School of Chemical and Process Engineering, University of Leeds)

Presentation materials